A study was done to compare the effectiveness of surgery compared to
radiation therapy in controlling cancer. A researcher obtained historical
records for patients who had been treated for a particular cancer, either
by surgery or radiation therapy. For the n1 patients who had surgery,
f11 showed improvement, f12 did not change, and f13showed improvement. For the n2 patients who had radiation therapy
f21 showed improvement, f22 did not change, and f23showed improvement. The data can be summarized as follows:
Outcome
| Treatment |
No Improvement |
No Change |
Some Improvement |
Totals |
| Surgery |
f11 |
f12 |
f13 |
n1 |
| Radiation Therapy |
f21 |
f22 |
f23 |
n2 |
| Totals |
f+1 |
f+2 |
f+3 |
|
The researchers desire to determine if there is a difference in the
distributions of outcomes between the two treatments, surgery and
radiation therapy. Let pij denote the probability that a patient in
treatment i (i=1,2) has outcome j=1,2,3. For example, p12denotes the probability that a patient in group 1, the surgery group,
shows no change, outcome category 2. The two samples, of sizes n1 and
n2, are independent.
The null hypothesis of interest is:
Derive the likelihood ratio test for this hypothesis. What is the name of
a commonly used test procedure used to test this hypothesis? How is it
related to the likelihood ratio test?